1. i) Basic Principles of cell injury and adaptation
a) Causes, Pathogenesis and morphology of cell injury
b) Abnormalities in lipoproteinaemia, glycogen infiltration and glycogen storage diseases
ii) Inflammation
a) Pathogenesis of acute inflammation, Chemical mediators in inflammation, Types of Chronic inflammation.
b) Repairs of wounds in the skin, factors influencing healing of wounds.
2. i) Diseases of Immunity
a) Introduction to T and B cells
b) MHC proteins or transplantation antigens
c) Immune tolerance
Hypersensitivity type I, II, III, IV, Biological significance, Allergy due to food, chemicals and drugs.
Criteria for autoimmunity, classifications of autoimmune diseases in man, Mechansim of autoimmunity, Transplantation and immunologic tolerance, allograft rejection, Transplantation antigens, Mechanism of rejection of allograft
-Acquired Immune Deficiency Syndrome (AIDS)
ii) Infectious diseases:
Sexually transmitted diseases (HIV, Syphilis, Gonorrhea), Urinary tract infecitons, Pneumonia, Typhoid, Tuberculosis, Leprosy, Malaria, Dysentery (bacterial and amoebic), Hepatitis-infective hepatits
3. Cancer: Differences between benign and malignant tumours, Histological diagnosis of malignancy, invasions and metastasis, patterns of spread, disturbances of growth of cells, classification of tumors, general biology of tumors, spread of malignant tumors, etiology and pathogenesis of cancer.
4. a) Types of shock, mechanisms, stages and management
b) Biological effects of radiation
c) Environmental and nutritional diseases
i) Air pollution and smoking- SO2, NO, NO2 and CO
ii) Protein calorie malnutrition, vitamins, obesity, pathogenesis of starvation
5. i) Pathophysiology of common diseases
a) Parkinsonism
b) Schizophrenia
c) Depression and mania
d) Hypertension
e) Stroke (Ischaemic and Hemorrhage)
f) Angina, CCF, Atherosclerosis, Myocaridal infarction
g) Diabetes Mellitus
h) Peptic ulcer and Inflammatory bowel diseases
i) Cirrhosis and Alcoholic Liver Diseases
j) Acute and Chronic Renal Failure
K) Asthma and Chronic Obstructive Airway Diseases