Basic principles of Cell injury and Adaptation:
• Introduction, definitions, Homeostasis
• Components and Types of Feedback systems
• Causes of cellular injury
• Pathogenesis (Cell membrane damage, Mitochondrial damage, Ribosome damage, Nuclear damage)
• Morphology of cell injury – Adaptive changes (Atrophy, Hypertrophy, hyperplasia, Metaplasia, Dysplasia)
• Cell swelling, Intracellular accumulation, Calcification, Enzyme leakage and Cell Death
• Acidosis & Alkalosis, Electrolyte imbalance

Basic mechanism involved in the process of inflammation and repair:
• Introduction, Clinical signs of inflammation
• Different types of Inflammation
• Mechanism of Inflammation – Alteration in vascular permeability and blood flow, migration of WBC's
• Mediators of inflammation
• Basic principles of wound healing in the skin

• Pathophysiology of Atherosclerosis

Cardiovascular System:
• Hypertension
• Congestive heart failure
• Ischemic heart disease (angina, myocardial infarction, atherosclerosis and
ii) Infectious diseases:
Sexually transmitted diseases (HIV, Syphilis, Gonorrhea), Urinary tract infecitons, Pneumonia, Typhoid, Tuberculosis, Leprosy, Malaria, Dysentery (bacterial and amoebic), Hepatitis-infective hepatits


Respiratory system:
• Asthma
• Chronic obstructive airways diseases
Renal system:
• Acute and chronic renal failure

Haematological Diseases:
• Iron deficiency
• Megaloblastic anemia (Vit B12 and folic acid)
• Sickle cell anemia
• Thalassemia

• Hereditary acquired anemia
• Hemophilia

Endocrine system:
• Diabetes

• Thyroid diseases
• Disorders of sex hormones

Nervous system:
• Epilepsy

• Parkinson's disease
• Stroke
• Psychiatric disorders: depression, schizophrenia and Alzheimer's disease

Gastrointestinal system: • Peptic ulcer
Unit IV
Inflammatory bowel diseases

• Jaundice

• Hepatitis (A, B, C, D, E, F)
• Alcoholic liver disease

Diseases of bones and joints
Rheumatoid arthritis



Principles of cancer:
• Classification
• Etiology and pathogenesis of cancer

4. a) Types of shock, mechanisms, stages and management
b) Biological effects of radiation
c) Environmental and nutritional diseases
i) Air pollution and smoking- SO2, NO, NO2 and CO
ii) Protein calorie malnutrition, vitamins, obesity, pathogenesis of starvation

Unit V
Infectious diseses

• Typhoid
• Leprosy
• Tuberculosis
• Urinary tract infections
Sexually transmitted diseases:
• Syphilis
• Gonorrhea